Cushing disease—long-term outcome after transsphenoidal surgery
نویسندگان
چکیده
منابع مشابه
Long-term follow-up on Cushing disease patient after transsphenoidal surgery
Cushing disease is caused by excessive adrenocorticotropic hormone (ACTH) production by the pituitary adenoma. Transsphenoidal surgery is its first-line treatment. The incidence of Cushing disease in children and adolescents is so rare that long-term prognoses have yet to be made in most cases. We followed-up on a 16-year-old male Cushing disease patient who presented with rapid weight gain and...
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BACKGROUND Inferior petrosal sinus sampling (IPSS) is a useful technique for confirming a pituitary source of adrenocorticotropic hormone (ACTH) overproduction in Cushing disease. Uncertainty remains regarding the appropriate course of therapy when an ectopic tumor is predicted by IPSS but none can be found and in circumstances when the procedure cannot be successfully completed owing to techni...
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BACKGROUND Olfaction has been demonstrated to have a great impact on patients' lives. Transsphenoidal endoscopic pituitary surgery is associated with potentially significant damage to olfactory tissues, but to date this issue has been only poorly documented in the literature. STUDY DESIGN Prospective cohort study comparing olfactory outcomes pre- and postpituitary surgery. METHOD Patients w...
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To evaluate possible risk factors for meningitis, we retrospectively reviewed 228 transsphenoidal operations (in which a standard regimen of amoxicillin prophylaxis was used) for sellar pathology. The incidence of meningitis was 3.1% (seven of 228 cases). Cultures of preoperative specimens from the anterior nasal vestibule in three of seven patients yielded Staphylococcus aureus, but none of th...
متن کاملTranssphenoidal surgery for Cushing's disease: defining cure and following outcome.
Ideally, selective and complete removal of a corticotroph adenoma should cure Cushing's disease and leave no other pituitary dysfunction. Furthermore, endocrinologists should be in a position to inform patients with Cushing's disease whether they are cured following transsphenoidal surgery. As with diagnosis of this condition, however, definition of cure continues to be debated. Such definition...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2012
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2012.20